An E3 Ubiquitin Ligase

Synaptic Research conducts research in three major areas with the goal of developing products based on this research:

  1. Construction of designer ubiquitin ligases to selectively control the ubiquitin system and thereby treat diseases, starting with the development of a post-exposure therapeutic for botulism.
  2. Methods to identify the presence of the botulinum toxin, using reliable, low-cost indicators. Identification is important both for food-borne toxins and as a defensive measure if botulism is used as a bio-weapon.
  3. Use of the botulinum toxin in medical or cosmetic applications. The use of the toxin in such applications has become a major commercial activity.

Other novel applications are also being researched.