TECHNOLOGY OVERVIEW Synaptic Research conducts research in three major areas with the goal of developing products based on this research: 1. Construction of designer ubiquitin ligases to selectively control the ubiquitin system and thereby treat diseases, starting with the development of a post-exposure therapeutic for botulism. 2. Methods to identify the presence of the botulinum toxin, using reliable, low-cost indicators. Identification is important both for food-borne toxins and as a defensive measure if botulism is used as a bio-weapon. 3. Use of the botulinum toxin in medical or cosmetic applications. The use of the toxin in such applications has become a major commercial activity. Other novel applications are also being researched.

Technology

PATENTS Synaptic Research holds several patents either through assignment or through exclusive licenses. The company also has several patents pending. Following are links to several of these patents or applications: Methods for Identifying Inhibitors of Botulinum Neurotoxins Fusion Proteins that Specifically Inhibit Protein Synthesis in Neuronal Cells (not yet available online)

The Botulinum Neurotoxin (BoNT) works on the neuromuscular junction. This electron micrograph shows a cross section of the neuromuscular junction. T is the axon terminal, M is the muscle fiber. Source: National Institutes of Mental Health.