Officers

Dr. George A. Oyler is the President of Synaptic Research. He holds MD
and PhD degrees in neuroscience. Prior to forming Synaptic Research,
Dr. Oyler was affiliated with several prestigious research and medical
institutions, including the Scripps Research Institute, Pennsylvania State
University, Johns Hopkins University, and the University of Maryland.

Dr. Oyler is a recognized expert in the biochemistry of neural function,
with particular emphasis on the effect of neurotoxins, especially the
Botulinum Toxin. His expertise in this area began in 1989 with the
publication of one of the seminal research papers in this field. Since then
his work has led to development of techniques for the analysis of toxin
effects on neurons, and subsequently to innovative strategies for the
treatment of exposure to neurotoxins. More recently, his research has
led to investigation of the ubiquitin system and how it might be used to
treat diseases, including botulism and other toxin-related diseases. He
has several patents pending in these fields.

As President of Synaptic Research, Dr. Oyler guides the company's
research into the use of designer ubiquitin ligases for treatment of
diseases, including post-exposure treatment of botulism. The company
also conducts research into pharmaceutical and cosmetic products
based on large-protein molecules derived from toxins.